Posted by starting from IP 76.169.65.71 on March 27, 2008 at 20:14:37:
A 32-year-old white male has been complaining of abdominal pain, flatulence, diarrhea, and weight loss for the past month. He denies blood in the stool and has had no recent dietary changes. He has no significant past medical history and does not take any medications. Vital signs are temperature 37°C (98.6°F), blood pressure (BP) 138/77 mm Hg, pulse 62 beats per minute, and respirations 12 breaths per minute. Physical examination reveals right lower abdominal tenderness and a negative stool occult blood. He does report that his older brother was recently diagnosed with Crohn disease and has been receiving treatment with moderate success. This patient is concerned that he may also have Crohn disease and asks for a biopsy to be performed. What is the most likely finding on histologic examination?
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A. Closely packed straight tubular glands with mucous secreting goblet cells and a nonspecific inflammatory reaction in the lamina propria
B. Exudate of mucin, necrotic epithelium, and neutrophils with intact basal crypts
C. Inflammation confined to the mucosa only
D. Transmural inflammation with noncaseating granulomas
E. Villous blunting from mild to totally flat mucosa
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