Posted by luther from IP 220.127.116.11 on September 15, 2015 at 13:59:51:
A patient you are following in the hospital is not responding to appropriate doses of phenytoin therapy(blood levels=1.8mg/dl).The decision is made to begin phenobarbitone therapy immediately.The doctor requests you to suggest a loading
regimen for this 70kg male patient to achieve a blood level of 2.0mg/dl within 24 hours(volume of distribution of phenobarbitone= 0.75l/kg).your suggestion would be;
(e) it is not possible to calculate regimen without additional data
please give an explanation/calculation to your answer.
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