Posted by Valery from IP 126.96.36.199 on March 25, 2012 at 18:09:44:
There are 3 types of congenital adrenal hyperplasia (CAH):
1. 21-hydroxylase deficiency that is expressed in decreased level of cortisol and normal aldosteron. This enzyme catalyzes the reaction of conversion of 17-hydroxyprogesteron into 11-deoxycortisol.
2. salt-losing syndrome which is associated with 21-hydroxylase deficiency also, but is expressed in both cortisol and aldosteron deficiency.
As far as I see, in the second case the higher level of pathway of cholesterol is involved – the conversion of progesterone into 11-deoxycorticosteron and 17-hydroxyprogesteron.
The only way to explain the expression of the deficit of the same enzyme is different way is: the first reaction is more sensitive to changes of the 21-hydroxylase concentration.
I have not found any explanation to this issue in the available literature, so I ask you for correction, if I am wrong, and for approval, if I am right.
Thank you for your time.
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