Posted by swati from IP 18.104.22.168 on February 27, 2012 at 06:59:18:
In Reply to: Acetaminophen toxicity posted by Anuj on February 24, 2012 at 08:06:11:
I got this in Pharmacology (Katzung):
The mechanism of toxicity requires oxidation to Cytotoxic intermidates by p450 enzymes.
This occurs if substrates for phaseII conjugation reactions (acetate & glucuronide) are lacking.
The intermidate (Ac) is conjugated with glutathion to harmless product .
If glutathion is exhausted Ac combines with hepatic cell proteins, resulting in cell death.
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