Posted by usmlestudy2010 from IP 18.104.22.168 on May 19, 2010 at 19:00:59:
The kinetic of a new pharmaceutical are being tested in an animal model.A drop of 50mg of the substance is injected I/V in to a rat.The concentration of the substance in the animal's blood is measured every 30minutes thereafter for the next 10hours.The concentration of the drug plotted against time produces the graph(1st order,2nd order kinetics graphs)
t1/2= (0.7X Vd)/clearance from this equation Vd=857
Question is how calculation was done to get 857 ?
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