Let's do Pathology cases-15

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Posted by JK from IP 129.252.69.45 on July 17, 2008 at 15:37:16:

15. A 43-year-old man is being followed for worsening involuntary jerky movements. During the course of his disease, he develops depression and progressive dementia. Within several years he dies, and during an autopsy, bilateral atrophy of the caudate nuclei is found. What is the basic abnormality involved in this individual’s disease process?

A. Acquired enzyme deficiency
B. DNA repair defect
C. Slow virus infection
D. Toxic chemical exposure
E. Triple repeat mutation

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