Posted by sally from IP 71.37.237.92 on July 30, 2006 at 14:19:32:
In Reply to: please explain these posted by img on July 30, 2006 at 12:52:19:
The basis of sepsis is the presence of infection and the subsequent physiologic alterations in response to that infection, namely the activation of the inflammatory cascade. Systemic inflammatory response syndrome (SIRS) is a term used to define this clinical condition, and it is considered present if abnormalities in 2 of the following 4 clinical parameters exist: (1) body temperature, (2) heart rate, (3) respiratory rate, and (4) peripheral leukocyte count.
Sepsis is defined as the presence of SIRS in the setting of infection. Severe sepsis is defined as sepsis with evidence of end-organ dysfunction as a result of hypoperfusion. Septic shock is defined as sepsis with persistent hypotension despite fluid resuscitation and resulting tissue hypoperfusion.
So, Decrease in volume leads to decreased preload
CVP, PAWP
Decrease in volume leads to decreased CO and MAP
Compensatory mechanisms try to correct these changes
Catecholamine release will increase SVR.
I hope it's clear for you now.